Table 3.
AUC, Cmax, and Cmin following the first, second, and third doses of gentamicin given before (Regimen A) or after (Regimens B-E) hemodialysis
| Regimen | First Dose
|
Second Dose
|
Third Dose
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| AUC (μg · h per ml) | Cmax (μg/ml) | Cmin (μg/ml) | AUC (μg · h per ml) | Cmax (μg/ml) | Cmin (μg/ml) | AUC (μg · h per ml) | Cmax (μg/ml) | Cmin (μg/ml) | |
| A | 383 ± 102 | 13.1 ± 2.06 | 6.31 ± 2.76 | 245 ± 74.5 | 7.94 ± 1.21 | 4.12 ± 1.99 | 236 ± 71.3 | 7.48 ± 1.11 | 3.04 ± 1.87 |
| B | 192 ± 46.4 | 22.9 ± 3.60 | 2.44 ± 1.21 | 220 ± 65.3 | 25.3 ± 3.72 | 2.85 ± 1.57 | 225 ± 70.7 | 25.7 ± 3.78 | 2.36 ± 1.66 |
| C | 219 ± 53.0 | 26.1 ± 4.11 | 2.79 ± 1.38 | 197 ± 61.6 | 22.4 ± 3.30 | 2.57 ± 1.45 | 195 ± 62.2 | 22.1 ± 3.26 | 2.05 ± 1.45 |
| D | 170 ± 41.0 | 20.3 ± 3.19 | 2.16 ± 1.07 | 176 ± 53.3 | 20.1 ± 2.96 | 2.29 ± 1.27 | 178 ± 56.1 | 20.2 ± 2.98 | 1.86 ± 1.31 |
| E | 165 ± 39.7 | 19.6 ± 3.09 | 2.09 ± 1.04 | 189 ± 56.0 | 21.7 ± 3.19 | 2.45 ± 1.34 | 193 ± 60.6 | 22.0 ± 3.24 | 2.03 ± 1.42 |
Values are mean ± SD. Regimens and targets are described in the text.