Table 4.

Percent of simulated patients at AUC, C_max, and C_min following the first, second, and third doses of gentamicin given before (Regimen A) or after (Regimens B-E) hemodialysis

Regimen	First Dose					Second Dose					Third Dose
	AUC (μg · h per ml)			Cmax (μg/ml) ≥8	Cmin (μg/ml) <2	AUC (μg · h per ml)			Cmax (μg/ml) ≥8	Cmin (μg/ml) <2	AUC (μg · h per ml)			Cmax (μg/ml) ≥8	Cmin (μg/ml) <2
	≤240	≥140	140–240			≤240	≥140	140–240			≤240	≥140	140–240
A	8.0	99.4	7.4	99.8	7.4	46.4	90.4	36.8	45.6	16.8	51	90.2	41.2	31.8	33.6
B	84.4	85.2	69.6	100	38	64.2	88.2	52.4	100	32.6	61	88.2	49.2	100	47.4
C	64.8	93.4	58.2	100	30	75.6	79.8	55.4	100	39	77	78.8	55.8	100	53.8
D	95.8	74.6	70.4	100	44.2	87.6	73.2	60.8	100	44	86.4	73.2	59.6	100	58.8
E	96.8	71.8	68.6	100	47.4	81.8	78.2	60	100	39.8	78.4	78.8	57.2	100	54.6

Targets represents those with AUC less than or equal to 240 μg/h per ml, greater than or equal to 140 μg/h per ml, and 140 to 240 μg/h per ml; peak concentrations more than the target of 8 μg/ml or those with minimum concentrations less than 2 μg/ml.