Table 3.
Cardiac natriuretic peptides by renal function status and diabetes
| Parameter | n | Anephric (GFR < 1 ml/min) | n | Nonanephric (GFR > 1 ml/min) | P value |
|---|---|---|---|---|---|
| All patients | |||||
| NT-proBNP (pg/ml) | 429 | 17,396 ± 14,067 | 356 | 8364 ± 11,729 | <0.0001 |
| proANP(1–30) (nmol/L) | 277 | 2.95 ± 2.25 | 245 | 1.89 ± 1.92 | <0.0001 |
| proANP(1–98) (nmol/L) | 277 | 0.67 ± 1.06 | 245 | 0.55 ± 0.89 | NS |
| proANP(31–67) (nmol/L) | 276 | 3.91 ± 1.90 | 245 | 3.20 ± 1.77 | <0.0001 |
| Diabetic patients | |||||
| NT-proBNP (pg/ml) | 156 | 18,443 ± 13,865 | 185 | 10,314 ± 12,369 | <0.0001 |
| proANP(1–30) (nmol/L) | 101 | 2.81 ± 2.23 | 132 | 1.97 ± 1.92 | <0.01 |
| proANP(1–98) (nmol/L) | 101 | 0.59 ± 0.99 | 132 | 0.51 ± 0.83 | NS |
| proANP(31–67) (nmol/L) | 100 | 3.96 ± 1.88 | 132 | 3.33 ± 1.77 | <0.01 |
| Nondiabetic patients | |||||
| NT-proBNP (pg/ml) | 273 | 16,798 ± 14,172 | 171 | 6254 ± 10,632 | <0.0001 |
| proANP(1–30) (nmol/L) | 176 | 3.03 ± 2.26 | 113 | 1.80 ± 1.93 | <0.0001 |
| proANP(1–98) (nmol/L) | 176 | 0.72 ± 1.09 | 113 | 0.59 ± 0.95 | NS |
| proANP(31–67) (nmol/L) | 176 | 3.89 ± 1.92 | 113 | 3.04 ± 1.76 | <0.001 |
Values are mean ± SD. There was no difference between diabetic or nondiabetic patients for any of the peptides in either the anephric or the nonanephric groups.