Table 3.

Changes of adiponectin, MCP-1, IL-6, and urinary ACR^a

Parameter	Sarpogrelate		Aspirin		Pb
	Before	After	Before	After
Adiponectin (μg/ml; median [range])	7.90(1.20 to 26.80)	12.00(4.20 to 29.10)b	7.70(2.20 to 25.40)	6.90(2.00 to 24.10)
log values (mean ± SEM)	0.87 ± 0.06	1.06 ± 0.05c	0.90 ± 0.05	0.85 ± 0.06
Δ changes (mean ± SEM)	4.39 ± 1.10		−0.59 ± 0.45		<0.001
% changes (mean ± SEM)	79.60 ± 29.10		−7.30 ± 5.38		<0.001
MCP-1 (pg/ml; median [range])	153.00(95.40 to 219.00)	114.00(64.30 to 168.00)c	139.00(105.00 to 362.00)	127.00(17.10 to 226.00)
log values (mean ± SEM)	2.17 ± 0.02	2.05 ± 0.03c	2.18 ± 0.03	2.09 ± 0.06
Δ changes (mean ± SEM)	−35.00 ± 8.55		−21.40 ± 13.40		<0.01
% changes (mean ± SEM)	−20.10 ± 6.21		−9.09 ± 8.33		<0.01
IL-6 (pg/ml; median [range])	0.68(0.20 to 3.40)	0.61(0.20 to 4.30)	0.77(0.20 to 2.30)	0.61(0.20 to 3.90)
log values (mean ± SEM)	−0.13 ± 0.07	−0.11 ± 0.09	−0.16 ± 0.07	−0.10 ± 0.08
Δ changes (mean ± SEM)	0.25 ± 0.29		0.23 ± 0.26
% changes (mean ± SEM)	104.00 ± 64.50		112.00 ± 68.30
Urinary ACR (mg/g Cr; median [range])	267.00(106.00 to 1580.00)	204.00(51.00 to 1160.00)c	173.00(105.00 to 2130.00)	196.00(86.00 to 2121.00)
log values (mean ± SEM)	2.50 ± 0.08	2.34 ± 0.08c	2.40 ± 0.10	2.43 ± 0.10
Δ changes (mean ± SEM)	−129.00 ± 43.20		34.70 ± 25.50		<0.001
% changes (mean ± SEM)	−22.80 ± 9.40		15.50 ± 11.60		<0.001
Urinary MCP-1 (pg/mg Cr; median [range])	879.00(34.90 to 7330.00)	729.00(50.90 to 5100.00)c	677.00(38.90 to 6974.00)	864.00(31.40 to 5732.00)
log values (mean ± SEM)	2.77 ± 0.18	2.66 ± 0.15c	2.77 ± 0.17	2.81 ± 0.15
Δ changes (mean ± SEM)	−441.60 ± 257.40		−57.20 ± 123.90		<0.001
% changes (mean ± SEM)	−2.53 ± 20.40		40.90 ± 38.30		<0.001

^aMCP-1, monocyte chemoattractant protein-1; ACR, urinary albumin-to-creatinine ratio.

^bSarpogrelate versus aspirin.

^cP < 0.01, before versus after.