Table 3.

Estimated glomerular filtration rate and incident early AMD

	Incident Early AMD		Odds Ratio (95% confidence interval)
	No. at Risk	No. (%) Affected	Age-, Sex-, CFH Y402H Genotype-Adjusted	P	Multivariable Adjusteda	P
Per SD decrease eGFRCG	1183	85 (7.2)	2.0 (1.4–2.8)	<0.0001	2.0 (1.5–2.8)	<0.0001
By CFH Y402H genotype
in noncarriers/heterozygotes (YY/YH)	696	59 (8.5)	1.8 (1.2–2.6)	0.003	1.7 (1.2–2.6)	0.008
in homozygotes (HH)	487	26 (5.3)	2.5 (1.3–4.8)	0.006	2.6 (1.3–5.3)	0.009
Per SD decrease eGFRMDRD	1183	85 (7.2)	1.6 (1.3–2.1)	0.0002	1.6 (1.3–2.1)	0.0001
Per SD increase serum creatinine			1.3 (1.1–1.5)	0.008	1.3 (1.1–1.5)	0.008

Units in either ml/min/1.73m² (eGFR) or mg/dl (creatinine). AMD, age-related macular degeneration; eGFR_CG and eGFR_MDRD, estimated glomerular filtration rate (in ml/min/1.73m²) using the Cockcroft-Gault and MDRD formulae, respectively; SD, standard deviation (14.8 ml/min/1.73m² for eGFR_CG; 12.5 ml/min/1.73m² for eGFR_MDRD; 0.24 mg/dl for creatinine).

^aAdjusted for age (continuous), sex, hypertension (present, absent), systolic blood pressure, diastolic blood pressure (both continuous), diabetes (present, absent), cigarette smoking (current, ex), pack-yr of cigarette smoking, white cell count, plasma fibrinogen, fasting plasma cholesterol, fasting plasma triglycerides (all continuous), CFH Y402H genotype (homozygous, heterozygous, noncarrier), and body mass index (continuous).