Figure 6.

Electron microscopic analysis of Nephrin-Noggin mice at birth. (A and B) Glomeruli from wild-type (A) and Nephrin-Noggin (B) mice. Boxed area in B shows parietal epithelial cells. (C and D) High-power field views. (A and C) A glomerulus from a wild-type mouse showing a normal visceral epithelial cell (VEp) and a parietal epithelial cell (PEp). Foot processes are observed only in visceral epithelial cells. A glomerulus from a Nephrin-Noggin mouse shows parietal epithelial cells with foot processes (arrows in D). An endothelial cell (En) is present just outside Bowman's capsule, which is not observed in wild-type mice (A and C). Bar = 1.25 μm.