Table 3.
Urinary concentrations of chemokines and cytokines according to study groupa
| Markers | Individuals with Normoalbuminuria, Reference Group (n = 74) | Individuals with Microalbuminuria
|
Pb | |
|---|---|---|---|---|
| Nondecliners(n = 43) | Decliners(n = 28) | |||
| Measured concentrations (pg/ml) | ||||
| IL-6 | 0.7 (0.4, 1.4) | 0.5 (0.4, 1.2) | 1.2 (0.4, 12.0) | 0.0304 |
| IL-8 | 0.9 (0.2, 7.3) | 0.8 (0.1, 3.9) | 13.0 (2.7, 87.0) | 0.0001 |
| IP-10 | 4.9 (2.0, 48.0) | 4.6 (2.2, 37.0) | 47.0 (6.8, 217.0) | 0.0009 |
| MCP-1 | 39.0 (18.0, 70.0) | 51.0 (18.0, 78.0) | 76.0 (53.0, 168.0) | 0.0029 |
| MIP-1δ | 42.0 (12.0, 65.0) | 38.0 (13.0, 71.0) | 64.0 (47.0, 122.0) | 0.0014 |
| Concentrations adjusted for urinary creatinine (pg/mg creatinine) | ||||
| IL-6 | 0.9 (0.3, 2.0) | 1.1 (0.4, 1.8) | 1.6 (0.6, 15.0) | 0.0780 |
| IL-8 | 1.0 (0.3, 4.9) | 0.8 (0.1, 3.9) | 15.0 (3.1, 79.0) | 0.0001 |
| IP-10 | 5.1 (3.1, 60.0) | 5.3 (2.6, 66.0) | 49.0 (6.9, 228.0) | 0.0021 |
| MCP-1 | 49.0 (25.0, 90.0) | 59.0 (32.0, 89.0) | 95.0 (55.0, 198.0) | 0.0054 |
| MIP-1δ | 50.0 (16.0, 97.0) | 48.0 (10.0, 91.0) | 80.0 (48.0, 155.0) | 0.0215 |
a
Data are median (25th, 75th percentiles).
b
Kruskal-Wallis test of the null hypothesis that all three groups are from the same distribution.