Table 5.
Comparison of cC-GFR and concentrations of selected chemokines in urine specimens obtained on two separate examinations 3.5 yr apart in 31 patients with type 1 diabetes and microalbuminuria according to renal function decline statusa
| Examinations | Nondecliners(n = 18) | Decliners(n = 13) | Pb |
|---|---|---|---|
| cC-GFR (ml/min) | |||
| first | 133 | 136 | NS |
| second | 126 | 103 | 0.010 |
| IL-8 (pg/mg creatinine) | |||
| first | 5.1 | 48 | 0.007 |
| second | 0.9 | 23 | 0.003 |
| MCP-1 (pg/mg creatinine) | |||
| first | 61 | 88 | 0.080 |
| second | 58 | 85 | 0.090 |
| IP-10 (pg/mg creatinine) | |||
| first | 17 | 26 | NS |
| second | 21 | 38 | NS |
a
Data are medians. Spearman correlation coefficients between the first and second examinations for urinary concentrations for IL-8 = 0.73 (P < 0.001), MCP-1 = 0.59 (P < 0.005), and IP-10 = 0.02 (NS).
b
Wilcoxon test was used.