Table 3.

Cox regression analysis of cardiac mortality^a

Baseline Variable	HR	95% CI	P
Cumulative mean predialysis serum β 2M level during follow-up (per 10-mg/L increase)	1.10	0.99 to 1.21	0.079
Age (per 10-yr increase)	1.51	1.35 to 1.68	<0.001
Gender (female)	0.83	0.63 to 1.10	0.20
Race (black)	0.61	0.46 to 0.80	<0.001
Diabetes	1.88	1.45 to 2.44	<0.001
Years on dialysis (per 1-yr increase)	1.04	1.01 to 1.07	0.011
Urea distribution volume (per 1-L increase)b	1.01	0.98 to 1.03	0.43
ICED score (per 1-U increase)c	1.29	1.12 to 1.50	0.001
Serum albumin (per 1-g/dl increase)	0.49	0.35 to 0.70	<0.001
Residual kidney urea clearance (per 1-ml/min increase)d	0.83	0.61 to 1.12	0.23
High-flux dialysis	1.17	0.80 to 1.71	0.42
Ultrafiltration volume/postdialysis weight (per 1-L/70-kg increase)	1.19	1.07 to 1.33	0.001

^aAnalysis stratified by clinical center; n = 1813. The HR for the cumulative mean predialysis serum β₂M level remained 1.10 per 10-mg/L increase, after adjustment for baseline use of venous catheters and baseline hematocrit in addition to the covariates included the table. CI, confidence interval; HR, hazard ratio.

^bUrea distribution volume as determined by kinetic modeling.

^cSeverity score computed with diabetes excluded (21).

^dNormalized to 35 L of urea distribution volume.