Table 3.
Taxonomy of models for hemoglobin variation
| Parameter | Model Number
|
||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| Fixed Effect Parameters | Means Only | Straight Line (Covariance: Identity) | Straight Line (Covariance: Unstructured) | Straight Line (Covariance: Unstructured) | Straight Line (Covariance: Unstructured) |
| Intercept | 11.8 [11.5, 12.1]a | 11.8 [11.5, 12.1]a | 11.9 [11.6, 12.2]a | 12.5 [12.1, 12.9]a | 12.5 [12.1, 12.9]a |
| Epo dose | −0.15 [−0.22, − 0.08]a | −0.19 [−0.27, −0.11]a | |||
| Epo dose × timec | 0.03 [0.001, 0.06]b | ||||
| Random effect parameters | |||||
| SD Intercept | 1.22 | 1.29 | 1.63 | 1.51 | 1.52 |
| SD Time | NA | 0.45 | 0.63 | 0.59 | 0.58 |
| Corr (intercept, time) | NA | NA | −0.61 | −0.59 | −0.58 |
| SD Residual | 1.320 | 1.130 | 1.030 | 1.020 | 1.01 |
| Pseudo R2 | 0.267 | 0.391 | 0.403 | 0.415 | |
| LL | −593 | −587 | −578 | −569 | −566.8 |
| Model comparison | 2 vs. 1a | 3 vs. 2a | 4 vs. 3a | 5 vs 4b | |
a
P < 0.001;
b
P < 0.05.
c
Epo dose in 10,000 units/month.