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(A) Hematocrit in 11βHSD2−/− mice (▪) and age-matched C57BL/6J mice (□). Mice were studied at 35 d (n = 6 controls, 7 11βHSD2−/−), 60 d (7/7), 80 d (7/5), and 120 d (7/7) of age. (B) Blood volume in 80-d-old 11βHSD2−/− mice (n = 7) and C57BL/6J mice (n = 6), normalized per gram of body weight. (C) Plasma sodium. (D) Plasma potassium. Data are means ± SEM, and comparisons were made using either t test or ANOVA with a Bonferroni post hoc test. *P < 0.05; **P < 0.01.
