Figure 5.

Vascular contractility in aortic rings from 11βHSD2^−/− mice (▪) and age-matched C57BL/6J mice (○). Mice were studied at 35 (A), 60 (B), 80 (C), and 120 d of age (D) with six mice per genotype used at each time point. Concentration-response curves to acetylcholine are shown on the left and to noradrenalin on the right. Data are means ± SEM of the percentage relaxation/contraction to the response induced by 5-hydroxytryptamine/potassium chloride, respectively. Comparisons were made using either t test or ANOVA with a Bonferroni post hoc test. **P < 0.01.