Table 1.

Physiologic and biochemical data

Parameter	Baseline		4 Wk		8 Wk
	N	Mean ± SD	n	Mean ± SD	n	Mean ± SD
Body weight (g)
sham	12	336.5 ± 6.5	6	394.5 ± 10.5	6	436.9 ± 14.8
nephrectomy	12	336.9 ± 14.4	6	371.3 ± 16.4a	5	419.1 ± 10.2a
CLO	12	327.3 ± 12.1	6	365.7 ± 9.2a	5	384.0 ± 11.4a
IRB	12	337.5 ± 16.2	6	370.4 ± 15.3a	5	411.0 ± 15.6a
CLO/IRB	12	333.5 ± 11.5	6	373.8 ± 13.3a	6	400.0 ± 10.0a
BP (mmHg)
sham	12	110 ± 4	6	107 ± 3	6	113 ± 3
nephrectomy	12	111 ± 3	6	184 ± 6a	5	192 ± 6a
CLO	12	114 ± 4	6	176 ± 9a	5	188 ± 4a
IRB	12	118 ± 5	6	170 ± 7a	5	160 ± 8a,b
CLO/IRB	12	112 ± 4	6	173 ± 8a	6	144 ± 7a,b,c
24hUP (mg/24 h)
sham	12	9.23 ± 2.50	6	12.16 ± 1.33	6	12.42 ± 7.26
nephrectomy	12	9.31 ± 1.07	6	33.21 ± 14.71a	5	90.84 ± 15.92a
CLO	12	8.18 ± 1.56	6	21.52 ± 12.88a	5	51.35 ± 7.06a,b
IRB	12	8.79 ± 1.41	6	20.74 ± 12.33a	5	38.29 ± 4.06a,b,c
CLO/IRB	12	8.81 ± 1.96	6	19.71 ± 12.49a	6	29.74 ± 4.49b,c,d
Creatinine (μmol/L)
sham	12	37.60 ± 5.75	6	38.61 ± 7.75	6	41.55 ± 3.37
nephrectomy	12	39.60 ± 5.40	6	56.30 ± 8.46a	5	106.08 ± 6.39a
CLO	12	41.80 ± 8.84	6	55.80 ± 6.05a	5	60.60 ± 3.05a,b
IRB	12	40.90 ± 6.51	6	54.80 ± 6.43a	5	57.35 ± 7.85a,b
CLO/IRB	12	41.10 ± 7.84	6	48.30 ± 6.12a	6	51.60 ± 4.51a,b,c

^aP < 0.05 versus sham.

^bP < 0.05 versus nephrectomy.

^cP < 0.05 versus CLO.

^dP < 0.05 versus IRB.