Table 2.
Tubulointerstitial injury, peritubular capillary loss, and impaired angiogenesis of hypokalemic rats at weeks 2, 4, and 12a
| Week 2
|
Week 4
|
Week 12
|
||||
|---|---|---|---|---|---|---|
| NK | LK | NK | LK | NK | LK | |
| Osteopontin, %b | ||||||
| cortex | 0.96 ± 0.3 | 0.97 ± 0.3 | 1.21 ± 0.1 | 1.37 ± 0.8 | 1.02 ± 0.3 | 2.04 ± 0.5d |
| outer medulla | 3.52 ± 0.5 | 4.45 ± 0.9c | 2.9 ± 1.0 | 5.53 ± 0.5c | 3.36 ± 1.4 | 5.93 ± 0.7d |
| ED-1, cells/mm2 | ||||||
| cortex | 18.8 ± 6.2 | 20.8 ± 7.5 | 13.2 ± 2.1 | 22.8 ± 12.1 | 13.9 ± 3.5 | 35.9 ± 10.6d |
| outer medulla | 24.4 ± 7.5 | 232 ± 180c | 23.7 ± 6.2 | 363 ± 228c | 19.2 ± 4.8 | 470 ± 273d |
| PCNA, cells/mm2 | ||||||
| cortex | 18.7 ± 5.5 | 40.6 ± 8.8d | 17.2 ± 1.6 | 31.9 ± 6.5c | 18.5 ± 7.9 | 35.6 ± 18.5 |
| outer medulla | 28.5 ± 8.3 | 74.6 ± 15.8d | 22.8 ± 1.5 | 44.5 ± 13.1c | 24.9 ± 6.8 | 64.3 ± 30.5c |
| Thrombomodulin-positive area, %b | ||||||
| cortex | 3.61 ± 0.4 | 3.38 ± 0.5 | 3.77 ± 0.9 | 2.96 ± 0.7 | 3.73 ± 0.7 | 2.54 ± 0.6c |
| OSOM | 3.60 ± 0.6 | 3.05 ± 0.3 | 4.05 ± 0.4 | 2.36 ± 0.5c | 3.94 ± 0.8 | 1.82 ± 0.5d |
| ISOM | 4.35 ± 0.6 | 3.12 ± 0.6d | 4.31 ± 0.2 | 2.53 ± 0.4d | 4.65 ± 1.0 | 1.60 ± 0.9d |
| Double staining of thrombomodulin and PCNA, cells/mm2 | ||||||
| outer medulla | 87.3 ± 19 | 72.8 ± 22 | 76.1 ± 19 | 48.5 ± 11c | 63.7 ± 23 | 28.9 ± 17c |
a
Data are expressed as mean±SD. PCNA, proliferative cell nuclear antigen; OSOM, outer stripe of the outer medulla; ISOM, inner stripe of the outer medulla.
b
(%) represented the percentage of positive area for the staining.
c
P < 0.05,
d
P < 0.01 versus NK group at the same time point.