Table 3.

Individual SNP genotype associations, by logistic regression, with SNPs selected from the 5′ and 3′ regions of the gene after sliding window analysis of California ESRD cases versus controls

SNP name	Domain	Genotypesa	Control (n)	ESRD (n)	Univariate		Adjustedb
					Odds Ratio (CI)	P	Odds Ratio (CI)	P
CHGA promoter region: G-462A→T-415C→C-89A
G-462A	Promoter	G/G	91	29	1.00 (reference)	0.197	1.00 (reference)	0.704
		G/A	44	21	1.50 (0.77, 2.92)		1.27 (0.60, 2.72)
		A/A	4	4	3.14 (0.74, 13.34)		1.76 (0.33, 9.39)
T-415C	Promoter	T/T	53	25	1.00 (reference)	0.359	1.00 (reference)	0.154
		T/C	61	22	0.76 (0.39, 1.51)		0.63 (0.29, 1.38)
		C/C	26	6	0.49 (0.18, 1.34)		0.33 (0.10, 1.07)
C-89A	Promoter	C/C	112	45	1.00 (reference)	0.693	1.00 (reference)	0.56
		C/A	32	9	0.70 (0.31, 1.58)		0.59 (0.23, 1.54)
		A/A	3	0	No estimate		No estimate
CHGA Exon/3′-UTR and downstream region: C11825T→G12602C
C11825T	Exon 8/3′-UTR	TT	4	7	8.67 (2.33, 32.28)	<0.0001c	6.23 (1.44, 26.98)	0.006c
		TC	18	19	5.23 (2.36, 11.60)		3.31 (1.30, 8.41)
		CC	104	21	1.00 (reference)		1.00 (reference)
G12602C	3′ downstream	CC	10	1	0.41 (0.05, 3.45)	0.566	0.28 (0.02, 3.59)	0.512
		CG	75	13	0.71 (0.31, 1.62)		0.64 (0.23, 1.82)
		GG	57	14	1.00 (reference)		1.00 (reference)

^aGenotypes: Wild-type on top, heterozygous (middle) and variant allele (bottom), as defined by dbSNP in NCBI (analysis performed with major allele in study population set as reference level).

^bAssociation analyses are adjusted for age, BMI and gender; there was no estimate because of sparse data.

^cSignificant (P < 0.05).