Table 5.
North Carolina association of haplotype regions (5′ and 3′) identified via sliding window analysis between ESRD replication cases and controls
| Locus Segment/Haplotype Configuration | Control (n) | ESRD (n) | Univariate Odds Ratio of ESRD (CI) | Univariate Diplotype (P) | Adjusted Odds Ratio of ESRDa (CI) | Adjusted Diplotype (P)a |
|---|---|---|---|---|---|---|
| CHGA promoter haplotype: T-415C→C-89A | ||||||
| Presence of TA | 66 | 45 | 0.65 (0.42, 0.99) | 0.0425 | 0.62 (0.40, 0.98) | 0.0394 |
| Absence | 220 | 232 | 1.00 | 1.00 | ||
| CHGA Exon/3′-UTR and downstream haplotype: C11825T→G12602C | ||||||
| Presence of TC | 1 | 8 | 8.43 (1.05, 67.84) | 0.0452 | 11.77 (1.43, 96.77) | 0.0218 |
| Absence | 276 | 262 | 1.00 | 1.00 |
a
Association analysis are adjusted for age, BMI and gender.