Table 2.
Renal inflammatory genes that are significantly affected during severe AKI
| Gene Title | Gene Symbol | Fold Change
|
PubMatrix
|
||
|---|---|---|---|---|---|
| 6 h | 36 h | Renal IRI | Kidney Inflammation | ||
| Lipocalin 2 | Lcn2 | 67.91 | 137.43 | 7 | 2 |
| Chemokine (C-X-C motif) ligand 2 | Cxcl2 | 35.31 | 11.44 | 2 | 3 |
| FBJ osteosarcoma oncogene | Fos | 39.02 | 4.69 | 5 | 11 |
| IL-6 | Il6 | 38.25 | 4.65 | 31 | 324 |
| Chemokine (C-X-C motif) ligand 1 | Cxcl1 | 29.58 | 10.71 | 5 | 13 |
| S100 calcium binding protein A8 | S100a8 | 16.36 | 11.49 | 0 | 6 |
| Suppressor of cytokine signaling 3 | Socs3 | 15.68 | 11.25 | 0 | 1 |
| S100 calcium binding protein A9 | S100a9 | 16.08 | 10.65 | 0 | 3 |
| Fos-like antigen 1 | Fosl1 | 13.76 | 11.58 | 0 | 0 |
| Chitinase 3-like 3 | Chi3l3 | 10.87 | 9.03 | 0 | 0 |
| Prostaglandin-endoperoxide synthase 2 | Ptgs2 | 13.08 | 5.08 | 36 | 112 |
| Kruppel-like factor 6 | Klf6 | 6.95 | 10.14 | 0 | 0 |
| Protein C receptor, endothelial | Procr | 11.00 | 4.36 | 0 | 2 |
| Plasminogen activator, urokinase receptor | Plaur | 6.20 | 8.06 | 0 | 3 |
| IL-1 receptor type II | Il1r2 | 7.75 | 6.02 | 0 | 1 |
| Serum amyloid A 3 | Saa3 | 7.35 | 3.92 | 0 | 14 |
| Annexin A1 | Anxa1 | 5.04 | 5.99 | 0 | 3 |
| Nfkb inhibitor, zeta | Nfkbiz | 6.18 | 4.19 | 0 | 0 |
| Coagulation factor III | F3 | 6.61 | 3.66 | 8 | 23 |
| Inhibin beta-B | Inhbb | 6.27 | 3.99 | 0 | 0 |
| CD14 antigen | Cd14 | 5.58 | 4.38 | 0 | 25 |
| Chemokine (C-X-C motif) ligand 7 | Cxcl7 | 5.04 | 4.41 | 0 | 0 |
| Proteolipid protein 2 | Plp2 | 3.26 | 5.97 | 0 | 0 |
| Oncostatin M receptor | Osmr | 3.92 | 3.23 | 2 | 1 |
| Chemokine (C-C motif) ligand 6 | Ccl6 | 3.03 | 4.05 | 0 | 0 |
| Chemokine (C-X-C motif) ligand 4 | Cxcl4 | 2.93 | 3.75 | 1 | 0 |
| Prolactin receptor | Prlr | −2.87 | −5.01 | 0 | 2 |
| Protein C | Proc | −3.26 | −5.15 | 5 | 30 |
| Phosphoenolpyruvate carboxykinase 1 | Pck1 | −2.95 | −6.48 | 0 | 0 |
| Peroxisomal membrane protein 2 | Pxmp2 | −3.25 | −6.57 | 0 | 0 |
| Growth hormone receptor | Ghr | −3.26 | −9.56 | 1 | 1 |
Significance criteria: 2.85-fold change and 1% false discovery rate (see Concise Methods). IRI, ischemia reperfusion injury.