Table 3.

Lung inflammatory genes that are significantly affected during severe AKI

Gene Title	Gene Symbol	Fold Change		PubMatrix
		6 h	36 h	Lung Inflammation
Significant at 6-h timepoint
chemokine (C-C motif) ligand 9	Ccl9	4.11	1.86b	0
leukocyte immunoglobulin-like receptor B3	Lilrb3	3.63	1.80	0
thrombospondin 1	Thbs1	3.48	1.28	3
CD14 antigen	Cd14	3.21	1.71	30
CCAAT/enhancer binding protein (C/EBP), beta	Cebpb	2.99	1.98	1
phospholipase A2, group VII	Pla2g7	2.91	5.60	0
Fc receptor, IgE, high affinity I, gamma	Fcer1g	2.81	2.97	0
serum amyloid A 2	Saa2	2.59	1.32	12
fatty acid binding protein 4, adipocytea	Fabp4	−2.51	−2.44	0
roundabout homolog 1	Robo1	−2.69	−1.45	0
Significant at both timepoints
serum amyloid A 3	Saa3	15.99	6.42	3
chemokine (C-X-C motif) ligand 2	Cxcl2	14.67	2.69	17
IL-1 receptor, type II	Il1r2	5.88	11.34	0
inhibin beta-B	Inhbb	6.93	3.70	0
serum amyloid A 1	Saa1	5.91	2.45	9
suppressor of cytokine signaling 3	Socs3	5.47	2.41	0
chemokine orphan receptor 1	Cmkor1	3.57	3.71	1
chemokine (C-C motif) receptor 1	Ccr1	2.73	3.76	2
formyl peptide receptor, related sequence 2	Fpr-rs2	2.76	3.72	0
interleukin 4 receptor, alpha	Il4ra	2.42	3.87	4
Significant at 36-h timepoint
serine/cysteine peptidase inhibitor, clade A 3N	Serpina3n	2.03	7.72	0
lipocalin 2	Lcn2	1.64	5.81	3
FMS-like tyrosine kinase 1	Flt1	1.65	4.59	0
arachidonate 5-lipoxygenase activating protein	Alox5ap	2.29	3.80	0
S100 calcium binding protein A9	S100a9	1.55	3.57	6
chemokine (C-C motif) ligand 6	Ccl6	2.30	3.09	0
signal transducer and activator of transcription 3	Stat3	1.99	3.04	9
peptidoglycan recognition protein 1	Pglyrp1	1.37	2.83	0
IL-1 receptor-like 1	Il1rl1	−1.20	−2.70	3
chemokine (C-X-C motif) ligand 12	Cxcl12	−1.82	−3.57	2

Significance criteria: 2.38 fold change and 2% false discovery rate (see Concise Methods).

^aSignificantly affected after 30 min of ischemia (Figure 5A);

^bfailed significance testing.