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. Author manuscript; available in PMC: 2008 May 21.
Published in final edited form as: CRC Crit Rev Plant Sci. 2007 Mar;26(2):105–122. doi: 10.1080/07352680701252817

Figure 1. Structural similarity of DNA polymerases.

Figure 1

Crystal structures of a representative member of each of the five DNA polymerase families (A, T. aquaticus Pol I; B, RB69 Pol; C, E. coli Pol III; X, Pol λ and Y, S. solfataricus Dpo4) and retrotranscriptases (RT). All DNA polymerases contain a general fold that can be likened to a right hand, with fingers, palm and thumb subdomains, colored in different shades of blue. Additional subdomains, colored yellow, are specific for each family or individual enzyme. Exo, 3′-5′ exonuclease domain; Nt, N-terminal domain; PHP, Polymerase and Histidinol Phosphatase domain; 8 kDa, 8 kDa domain; LF, Little Fingers domain; RH, RNAse H domain; CD, Connecting domain.