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1’-OH midazolam formation by human CYP2C and CYP3A enzymes. The final concentration of midazolam in the incubations was 25 μM and 20 pmol of enzyme was used. After a preincubation of 5 min the reaction was started by adding a NADPH-regenerating system and the mixture was subsequently incubated for 10 minutes. All values are the means of duplicate determinations.
