Table 3.

Plasma pharmacokinetic parameters after i.v. administration of 0.5 or 10 mg/kg midazolam to Cyp3a^+/+ and Cyp3a^−/− mice.

	Midazolam		1′-OH Midazolam		4-OH Midazolam
	Cyp3a+/+	Cyp3a−/−	Cyp3a+/+	Cyp3a−/−	Cyp3a+/+	Cyp3a−/−
0.5 mg/kg
AUC(0−1.5h), hr.μg/L	29.5 ± 2.07	31.1 ± 4.03	29.7 ± 1.62	26.2 ± 3.25	0.95 ± 0.08	1.14 ±0.0
Cl, 1/hr.kg	0.017 ± 0.001	0.016 ± 0.002
10 mg/kg
AUC(0−1.5h), hr.μg/L	842 ± 168	833 ± 111	1849 ± 234	1147 ± 199 *	23.6 ± 5.1	15.8 ± 4
Cl, 1/hr.kg	0.012 ± 0.002	0.012 ± 0.002

AUC_(0−1.5h), area under plasma concentration-time curve up to 1.5 hr; Cl, plasma clearance. Data are means ± SD, n = 3−5. ^* P < 0.05.