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. 2008 Apr 29;98(10):1619–1629. doi: 10.1038/sj.bjc.6604352

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Copyright © 2008 Cancer Research UK

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Thrombospondin-1 (TSP-1) and VEGF secretion in HMVEC-d (A) cells exposed to SN-38 at a concentration corresponding to the experimental IC₅₀ of cell proliferation or with vehicle alone for 72 h. Thrombospondin-1 and VEGF concentrations in conditioned media were normalised to total protein concentration. Modulation of Akt (pThr³⁰⁸) phosphorylation by SN-38 in HMVEC-d cells after 72 h of treatment (B). Columns and bars, mean values ±s.e., respectively. ^*P<0.05 vs vehicle-treated controls.