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. 2008 Apr 8;98(10):1696–1703. doi: 10.1038/sj.bjc.6604326

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Copyright © 2008 Cancer Research UK

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Effect of MMC and hypoxia on IRES activity. Treatment with MMC significantly reduced cap-dependent translation of the Renilla luciferase (A) but resulted in an increase in the ratio of IRES-dependent to cap-dependent translation in both HCT116 (B) and PAN1 cells (C). Similarly, 24 h exposure to a hypoxic environment increased IRES-dependent translation (D). Statistical significance is indicated by ^*P<0.05 or ^**P<0.01.