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. 2008 May 13;98(10):1690–1695. doi: 10.1038/sj.bjc.6604333

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Copyright © 2008 Cancer Research UK

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Representative results of LOH and MSP in cases 10, 12, 21, and 2. In the analysis of LOH at RUNX3 locus, cases 10, 12, and 21 showed allelic imbalance at D1S234 as well as at D1S247 (arrowheads). Case 2 showed allelic imbalance at D1S234 (arrowhead), but the D1S247 was not informative (NI). Promoter hypermethylation was observed in the DNA extracted from tumour tissue (T). In noncancerous samples (N), a methylation band was not seen in any lane. All four cases showed both LOH and promoter hypermethylation. These results indicated that biallelic inactivation (LOH at 1p36+ methylation) caused the inactivation of RUNX3 in pancreatic cancer. LOH, loss of heterozygosity; MSP=methylation-specific PCR; RUNX3=human runt-related transcription factor 3 gene.