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. 2008 May 13;98(10):1690–1695. doi: 10.1038/sj.bjc.6604333

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Copyright © 2008 Cancer Research UK

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Sequence analysis of bisulphite-treated DNA from tumour sample of case 10 in RUNX3 promoter region. Methylation status of the 19 CpG islands between −82 and −202 from the transcription-initiation site of RUNX3 exon 1 is shown. The fragment was PCR amplified and subcloned into TA cloning vector. Closed circle indicates methylated CpG island, open circle indicates unmethylated CpG island. Each group of six clones showed a different methylation status. Arrows below the sequence indicate CpG islands. The Cs indicate methylated CpG islands. The Ts were converted from C by bisulphite treatment, indicating unmethylated CpG islands. RUNX3=human runt-related transcription factor 3 gene.