Table 2. Clinicopathological features and results of RUNX3 hypermethylation in pancreatic cancer tissues.
|
Hypermethylation
|
||||
|---|---|---|---|---|
| Variable | No. of cases | + | − | P a |
| Age | ||||
| <60 | 10 | 5 | 5 | 0.325 |
| ⩾60 | 22 | 15 | 7 | |
| Gender | ||||
| M | 18 | 13 | 5 | 0.198 |
| F | 14 | 7 | 7 | |
| Tumour size | ||||
| TS1 | 5 | 2 | 3 | >0.9999 |
| ⩾TS2 | 27 | 18 | 9 | |
| S | ||||
| − | 18 | 11 | 7 | 0.854 |
| + | 14 | 9 | 5 | |
| RP | ||||
| − | 10 | 6 | 4 | 0.844 |
| + | 22 | 14 | 8 | |
| CH | ||||
| − | 13 | 9 | 4 | 0.515 |
| + | 19 | 11 | 8 | |
| DU | ||||
| − | 21 | 13 | 8 | 0.923 |
| + | 11 | 7 | 4 | |
| PV | ||||
| − | 12 | 8 | 4 | 0.706 |
| + | 20 | 12 | 8 | |
| A | ||||
| − | 27 | 16 | 11 | 0.379 |
| + | 5 | 4 | 1 | |
| PL | ||||
| − | 27 | 16 | 11 | 0.379 |
| + | 5 | 4 | 1 | |
| DPM | ||||
| − | 26 | 15 | 11 | 0.242 |
| + | 6 | 5 | 1 | |
| N | ||||
| 0 | 14 | 8 | 6 | 0.581 |
| 1 | 18 | 12 | 6 | |
| Differentiation | ||||
| Mod | 21 | 12 | 9 | 0.241 |
| Poor | 6 | 5 | 1 | |
a
Analysed by Fisher's exact test or χ2 test for independence.
bTumour size according to the Classification of Pancreatic Carcinoma; A=arterial invasion; CH=choledocal invasion; DPM=dissected peripancreatic tissue margin; DU=duodenal invasion; F=female; PL=peripancreatic nerve plexus invasion; M=male; mod=moderately differentiated adenocarcinoma; N=lymph node metastasis; poor=poorly differentiated adenocarcinoma; pTNM=pathological TNM; PV=portal vein invasion; RP=retroperitoneal invasion; S=serosal invasion.
cClassified according to the classification of The General Rules for the Clinical and Pathological Study of Primary Pancreatic Cancer. April 2002, Pancreatic Cancer Study Group of Japan.