Table 6.
Overlapping chromosomal regions in weighted GSMA for asthma, and the three intermediate phenotypes
| ASTHMA | BHR | TOTAL IGE | SPT RESPONSE | ||||||||
| BIN(a) | GENETIC LOCUS(b) | DIST. (cM)(c) | PHYS POS. (KBp)(d) | p(SR) | p(OR) | p(SR) | p(OR) | p(SR) | p(OR) | p(SR) | p(OR) |
| 6 | 1p13.3-q23.3 | 142.24–170.84 | 110103–159125 | - | - | - | - | 0.06630 | 0.13155 | 0.02081 | 0.22906 |
| 7 | 1q23.3-q31.1 | 170.84–201.58 | 159125–185232 | - | - | - | - | 0.03099 | 0.14664 | 0.08924 | 0.13402 |
| 15 | 2p12-q22.1 | 101.56–128.41 | 79617–119705 | 0.79974 | 0.00694 | 0.00574* | 0.14743 | - | - | - | - |
| 24 | 3p14.1-q12.3 | 88.60–117.76 | 64182–103187 | 0.02348 | 0.80059 | 0.09312 | 0.17837 | - | - | 0.00298 | 0.00450* |
| 40 | 5q5q14.3-q23.2 | 97.82–131.48 | 88765–123774 | 0.71879 | 0.05004 | - | - | 0.09195 | 0.08596 | - | - |
| 41 | 5q23.2-q34 | 131.48–164.19 | 123774–162087 | 0.06027 | 0.77886 | 0.01511 | 0.09586 | 0.01890 | 0.40276 | - | - |
| 43 | 6pter-p22.3 | 0.00–32.62 | pter-16854 | 0.65433 | 0.03220 | - | - | 0.03276 | 0.02583 | - | - |
| 44 | 6p22.3-p21.1 | 32.62–65.14 | 16854–43207 | 0.03905 | 0.72593 | 0.00716* | 0.04861 | 0.00999 | 0.71984 | 0.09934 | 0.16043 |
| 45 | 6p21.1-q15 | 65.14–99.01 | 43207–90985 | - | - | 0.07128 | 0.19832 | - | - | 0.03654 | 0.12598 |
| 46 | 6q15-q23.2 | 99.01–131.07 | 90985–132584 | - | - | 0.09445 | 0.10925 | - | - | 0.03318 | 0.18839 |
| 50 | 7p21.1-p14.1 | 29.28–59.93 | 19430–40230 | 0.86218 | 0.01583 | 0.03597 | 0.24658 | 0.02708 | 0.41494 | - | - |
| 55 | 8pter-p22 | 0.00–27.40 | pter-13111 | 0.68196 | 0.01899 | - | - | - | - | 0.06027 | 0.07341 |
| 71 | 10q23.33-q26.13 | 117.42–142.78 | 95985–123274 | 0.85805 | 0.05664 | 0.16985 | 0.08106 | - | - | - | - |
| 76 | 11q13.3-q22.3 | 72.82–98.98 | 70185–103732 | - | - | 0.12913 | 0.01652 | 0.02792 | 0.22926 | - | - |
| 77 | 11q22.3-q24.1 | 98.98–123.00 | 103732–122977 | - | - | - | - | 0.08890 | 0.12887 | 0.04276 | 0.11460 |
| 78 | 11q24.1-qter | 123.00–147.77 | 122977-qter | - | - | 0.00505* | 0.46485 | - | - | 0.08072 | 0.12542 |
| 84 | 12q24.31-qter | 139.61–170.60 | 120806-qter | 0.02714 | 0.65821 | - | - | 0.07175 | 0.10909 | - | - |
| 85 | 13pter-q13.2 | 0.00–26.87 | pter-33636 | - | - | 0.05521 | 0.18686 | 0.08835 | 0.22042 | - | - |
| 92 | 14q32.12-qter | 105.00–138.18 | 90647-qter | 0.88932 | 0.00423* | - | - | - | - | 0.95708 | 0.07887 |
| 108 | 18q22.1-qter | 96.48–126.00 | 60025-qter | - | - | 0.08190 | 0.24216 | - | - | 0.96132 | 0.03480 |
| 115 | 20p11-q13.13 | 47.52–72.27 | 21259–46747 | 0.65424 | 0.06184 | 0.10563 | 0.03503 | - | - | - | - |
| 118 | 21q21.3-qter | 25.26–57.77 | 27903-qter | - | - | 0.20402 | 0.09140 | - | - | 0.03029 | 0.28738 |
Chromosomal regions with p(SR) or p(OR) < 0.1 in two or more weighted GSMA are shown. aBin number from GSMA (1–120 inclusive). bCytogenetic band (Taken from April 2002 Genome Browser, UCSC). cGenetic distance in Marshfield cM (not cumulative). dPhysical position in kilobase pairs (Taken from December 2006 UniSTS, NCBI/Genome Browser, UCSC). *p < 0.000417 = Genome wide significance for linkage, p < 0.0083 = Suggestive for linkage.