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. 2007 Aug 14;3(5):546–549. doi: 10.1098/rsbl.2007.0265

Figure 1.

Figure 1

(a) Genomic sequence alignments of intron 3/exon 4 boundary of α-LA from subantarctic (SFS), Cape (CFS) and northern fur seal (NFS), California (CSL) and Australian sea lion (ASL), Weddell (WS) and Ringed seal (RS), domestic dog (NP_001003129) and walrus (WAL). The mutation is bold and shaded in otariids α-LA, and dashes indicate the deletion in walrus α-LA. Exon 4 is underlined and bold. (b) Gene structure of α-LA (ALA) from domestic dog, Weddell seal and the two Cape fur seal variants (CFS (l), long; CFS (s), short). Intron 3 splice sites are shown. (c) Protein alignment of α-LA from Cape fur seal (long and short), Weddell seal, domestic dog (Q9N2G9), cow (P00711) and walrus (SFS and CSL α-LA proteins found to be identical to CFS; electronic supplementary material). Residues essential for lactose synthesis are underlined.