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. 2008 Jun;131(6):549–561. doi: 10.1085/jgp.200809962

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© 2008 Lewis et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Comparison of amino acid sequence of Shaker and Kv1.2 in the region of the S4 and S5 segments. (A) A model describing the membrane topology of a Kv1.2 subunit showing transmembrane segments S1–S6 and the reentrant P loop. The approximate positions of residues R294 of S4 segment and A351 of the S5 pore domain are indicated. (B) Alignment of S4–S5 regions of Kv1.2, Shaker, KvAP, and the recently crystallized chimera of Kv1.2-Kv2.1. The black line indicates the S4 and S5 transmembrane segments and the asterisks denote the position of residues R294 and A351 of Kv1.2. Highlighted in blue and red are basic and acidic residues, respectively.