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. 2008 Jun;131(6):575–587. doi: 10.1085/jgp.200709924

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© 2008 Jia et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — NGF inhibited M/KCNQ currents from SCG neurons. (A) NGF (20 ng/ml) inhibited M/KCNQ currents from both phasic (left) and tonic (right) neurons. Time course of tail M/KCNQ currents at −60 mV was shown. Linopirdine (30 μM) was used to establish the baseline for the measurements. Perforated patch method was used in these experiments. (B) Summary data for NGF-induced inhibition of M/KCNQ currents shown in A. (C) NGF (20 ng/ml) inhibited M/KCNQ currents in presence of 5 μM linopirdine. (D) Oxo-M (10 μM) inhibited M/KCNQ currents. (E) NGF (20 ng/ml) also inhibited M/KCNQ currents recorded using conventional whole-cell method. The right panel shows the current traces taken at the times indicated in the left panel. (F) Concentration–response relationship for NGF-induced inhibition of M/KCNQ current. (G) Summary data for the effects of AG879 (50 μM, 5 min), genistein (100 μM, 5–10 min), and U73122 (3 μM, 3–5 min) on NGF-induced inhibition of M/KCNQ currents recorded using conventional whole-cell method. **, P < 0.01. Error bars represent SEM.