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. 2008 Jun;131(6):575–587. doi: 10.1085/jgp.200709924

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© 2008 Jia et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — NGF enhanced firing of tonic neurons, whereas Oxo-M and linopirdine enhanced both tonic and phasic neuronal excitability. (A) Effects of Oxo-M (10 μM, ∼1 min), linopirdine (30 μM, ∼1 min), and NGF (20 ng/ml, ∼2 min) on firing of action potentials from tonic neurons. Perforated patch method was used in these experiments. (B and C) Summary data for number of spikes fired and resting membrane potential of tonic neurons, respectively. (D and E) Summary data for number of spikes fired and resting membrane potential of phasic-1 neurons, respectively. (F and G) Summary for number of spikes fired and resting membrane potential of phasic-2 neurons, respectively. LP is abbreviation of linopirdine. *, P < 0.05; **, P < 0.01. Error bars indicate SEM.