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. 2008 Jun;131(6):575–587. doi: 10.1085/jgp.200709924

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© 2008 Jia et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — Linopirdine at low concentrations mimicked NGF action on neuronal excitability. (A) The time course of M/KCNQ currents inhibited by different concentrations of linopirdine. The record is from a phasic neuron and the M/KCNQ current was recorded at −60 mV as described before. Perforated patch method was used in these experiments. (B) Concentration–response curve for linopirdine-induced inhibition of M/KCNQ currents fitted with the Hill function. IC₅₀ for linopirdine is 2.1 ± 0.2 μM, and the coefficient is 1.2 ± 0.1 (C, E, and G) The effects of linopirdine at 0.7 μM (LP, 0.7 μM) on firing of action potential from phasic-1, phasic-2, and tonic neurons, respectively. (D, F, and H) Summary data for C, E, and G, respectively. *, P < 0.05. Error bars indicate SEM.