Skip to main content
. 2008 May 22;118(6):2190–2199. doi: 10.1172/JCI33585

Figure 7. Increasing beclin 1 expression reduces amyloid pathology.

Figure 7

Lentivirus encoding for GFP or mouse beclin 1 (mbeclin 1) was injected into the left (GFP) or right (beclin 1) hippocampus and cortex of 6-month-old APP transgenic mice. (A) GFP and mouse beclin 1 expression 8 weeks after lentivirus injection into the hippocampus. (B and C) Intracellular Aβ (4G8) was reduced with mouse beclin 1 overexpression in the hippocampus (B) and frontoparietal cortex (B and C) of 8-month-old mice. (D) Extracellular β-pleated Aβ deposits measured by thioflavin S staining in the frontal cortex was also reduced by beclin 1 overexpression. Results were analyzed by unpaired Student’s t test (n = 4 per group). Values are mean ± SEM. Original magnification, ×10 (A); ×40 (B).