Figure 3.
CGH average ratio profiles of genomic DNA from liver tissue of wild-type (A) and PARP−/− (B) mice. Average ratio profiles were computed for all chromosomes and used for the mapping of changes in copy number. The three vertical lines to the right of the chromosome ideograms represent values of 0.75, 1, and 1.25 (left to right, respectively) for the fluorescence ratio between the test DNA and the normal control DNA. The ratio profile (curve) was computed as a mean value of at least eight metaphase spreads. A ratio of ≥ 1.25 was regarded as a gain and a ratio of ≤ 0.75 as a loss.