. Author manuscript; available in PMC: 2008 May 22.

Published in final edited form as: Pharmacogenet Genomics. 2007 Mar;17(3):169–180. doi: 10.1097/FPC.0b013e32801152d6

Table 3.

Single nucleotide polymorphisms (SNP) found in CYP26A1

SNP ID^a	Site	Nucleotide change	Amino acid change	Number of alleles^e
				Africans		Caucasians	Asians	Unknown	Position^d

				AA^b	AP^c
1671	Promoter	ccgtg(G>A)ggttt	Non coding	0/30	0/18	3/46	1/48	0/40	-59
1673	Promoter	ctggc(G>T)gcggc	Non coding	1/30	0/18	0/46	0/46	0/40	-36
1672	IVS1+10	gggag(G>C)gtggg	Non coding	8/30	4/18	0/48	2/46	4/40	+199
1669	IVS1-44	ccccg(G>A)cgccc	Non coding	3/30	0/18	0/48	0/48	0/40	+330
1670	IVS1-5	cctcc(C>T)acagc	Non coding	0/30	0/18	0/48	1/48	0/40	+369
1721	Exon3	gcgag(C>A)gcggc	Arg173Ser	3/30	0/18	0/48	0/48	0/40	+947
1720	Exon3	atgtt(C>A)cgaat	Phe186Leu	0/30	0/18	1/48	0/48	0/40	+988
1723	IVS4+7	tgagt (A>G)gcagc	Non coding	4/30	1/16	0/48	1/46	2/40	+1380
1722	IVS4+8	gagta(G>A)cagct	Non coding	4/30	1/16	0/48	1/46	2/40	+1381
1724	IVS4-8	actct(A>G)ttctt	Non coding	0/30	0/18	1/48	0/48	0/40	+1884
1726	Exon 6	tcggg(T>C)gtgtt	Cys358Arg	0/30	0/18	0/48	1/46	0/40	+2682
1725	IVS6+69	tgctg(T>G)ggctg	Non coding	0/30	1/18	0/48	0/46	1/40	+2901
1746	Exon 7	ggagg(C>G)cttag	Gly438Gly	0/30	0/16	0/46	2/48	0/40	+3190

The SNP ID numbers are from the NIEHS SNP database.

AA, African-American,

AP, African Pygmies.

Position number was based on the reference CYP26A1 gene sequence obtained from NCBI accession number, NT_030059.12 with the A of the start codon being +1, and negative numbers representing the upstream region. Intron changes are also denoted IVS followed the position relative to the exon . CYP26A1 was resequenced in DNA from 15 African-Americans (30 alleles), 9 African Pygmies (18 alleles), 24 Caucasians (48 alleles), 24 Asians (48 alleles) and 20 unknown racial group (40 alleles).