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. 2008 Mar 11;105(11):4318–4322. doi: 10.1073/pnas.0709144105

Fig. 2.

Fig. 2.

Single injection of AAV1-FS increases muscle mass and strength in young mdx mice. (a) Gross hindlimb muscle mass is increased in AAV1-FS-injected mdx animals at 180 days of age compared with AAV1-GFP-injected controls. (b) The mass of individual hindlimb and forelimb muscles is increased at 180 days of age in mice injected at 3 weeks of age with AAV1-FS compared with AAV1-GFP controls (n = 15). *, P ≤ 0.05. (c) Grip strength is improved in a dose-dependent manner in young mdx mice injected at 3 weeks of age with AAV1-FS followed for 180 days (n = 15). Red, high-dose AAV1-FS; blue, low- dose AAV1-FS; green, AAV1-GFP controls. Error bars represent standard errors.