Table 1.
Reproduction was normal in animals treated with AAV1-FS
| Reproductive study group | n | Mean litter size (SD) |
|---|---|---|
| C57Bl/10 | ||
| AAV1-FS-treated male × untreated female | 4 | 9.0 (2.582) |
| AAV1-FS-treated female × untreated male | 4 | 9.25 (1.708) |
| Untreated male × untreated female | 4 | 9.0 (2.160) |
| mdx | ||
| AAV1-FS-treated male × untreated female | 3 | 4.5 (0.707) |
| AAV1-FS-treated female × untreated male | 2 | 2.0 (0) |
| Untreated male × untreated female | 6 | 3.83 (1.169) |
Male and female C57BL/10 and mdx mice treated for either 2 years or 6 months, respectively, were able to breed normally with no differences in the litter size of treated animals compared with noninjected controls. (P > 0.05.)