Table 1.
The proportion of underexpressed metabolism-related genes in each of the sample brain regions
| Brain region | Complex I |
Complex II |
Complex III |
Complex IV |
Complex V |
TIMMs |
TOMMs |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of subunits | Fold | No. of subunits | Fold | No. of subunits | Fold | No. of subunits | Fold | No. of subunits | Fold | No. of subunits | Fold | No. of subunits | Fold | |
| PCC | 28/39 (72) | −3.0 | 2/4 (50) | −2.8 | 8/9 (89) | −3.6 | 7/13 (54) | −2.8 | 11/15 (73) | −3.8 | 3/11 (27) | −3.2 | 3/6 (50) | −2.6 |
| MTG | 27/39 (69) | −2.5 | 2/4 (50) | −2.5 | 6/9 (67) | −2.3 | 8/13 (62) | −2.4 | 9/15 (60) | −3.3 | 3/11 (27) | −2.2 | 5/6 (83) | −2.3 |
| HIP | 25/39 (64) | −2.5 | 2/4 (50) | −2.7 | 5/9 (56) | −2.8 | 7/13 (54) | −2.2 | 10/15 (67) | −2.7 | 3/11 (27) | −2.6 | 4/6 (67) | −2.7 |
| EC | 9/39 (23) | −4.5 | 0/4 (0) | 1/9 (11) | −3.7 | 3/13 (23) | −4.5 | 5/15 (33) | −4.3 | 5/11 (45) | −3.7 | 1/6 (17) | −2.8 | |
| VC | 7/39 (18) | −1.8 | 0/4 (0) | 1/9 (11) | −2.0 | 1/13 (8) | −1.5 | 4/15 (27) | −2.1 | 0/11 (0) | 1/6 (17) | −2.2 | ||
| SFG | 4/39 (10) | −3.9 | 0/4 (0) | 0/9 (0) | 0/13 (0) | 0/15 (0) | 2/11 (18) | −3.6 | 2/6 (33) | −2.4 | ||||
The numerator indicates the number of subunits showing statistically significant (P < 0.01 with multiple testing corrections) underexpression and the denominator indicates the total number of nuclear-encoded subunits for the complex/translocase. This ratio is expressed as a percentage in parentheses. PCC, posterior cingulate cortex; MTG, middle temporal gyrus; HIP, hippocampus; EC, entorhinal cortex; VC, visual cortex; SFG, superior frontal gyrus).