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. 2008 Mar 12;105(11):4312–4317. doi: 10.1073/pnas.0707370105

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© 2008 by The National Academy of Sciences of the USA

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Fig. 6. — Lethal toxin and Salmonella stimulate a common mechanism of lysis mediated by pore formation. (A–C) Macrophages were treated with LT, S. typhimurium (S.T), or 5 mM H₂O₂ in the presence of osmoprotectants of varying sizes (A and B) or glycine (B and C), which nonspecifically inhibits ion fluxes. (A and C) LDH released by dying cells was quantified; means ± SD are shown. *, P < 0.05 versus medium. (B) Macrophages containing active caspase-1 were identified by FAM-YVAD staining; means ± SD are shown.