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. 2008 Mar 12;105(11):4247–4252. doi: 10.1073/pnas.0800276105

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© 2008 by The National Academy of Sciences of the USA

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Fig. 3. — Cisplatin sensitivity and apoptosis in Mlh1^G67R/G67R MEF cells. MEF strains of the various Mlh1 genotypes were exposed to cisplatin for different time periods or at varying concentrations. (a) Survival of cells after exposure with 40 μM cisplatin at different time intervals. (b) Survival of cells after 48-h exposure at different cisplatin concentrations. (c) Apoptotic response to cisplatin treatment (20 μM cisplatin for 24 h) measured by TUNEL. (d) G₂/M cell-cycle arrest in Mlh1^G67R/G67R MEF cells. The percentage of cells in G₀/G₁ and G₂/M were calculated for three different MEF strains for indicated genotypes. The results are shown as the fold increase of G₂/M cells in treated over untreated MEFs for each genotype.