Fig. 3.

Histopathology of representative lesions. (A) Primary invasive moderately differentiated adenocarcinoma (enclosed by black boundary) arising in a tubular adenoma (enclosed by red boundary) from patient 10. (B) Primary invasive moderately differentiated adenocarcinoma (enclosed by black boundary) with adjacent nonneoplastic colonic mucosa (enclosed by red boundary) from patient 2. (C) Metastatic adenocarcinoma (enclosed by black boundary) to liver (enclosed by red boundary) derived from primary colon adenocarcinoma of patient 2. All sections were stained with H&E, and the tissues within each boundary were separately microdissected.