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. 2008 Mar 10;105(11):4265–4270. doi: 10.1073/pnas.0711271105

Fig. 1.

Fig. 1.

Structure and glycosylation of IgG. (A) Schematic representation of the fully substituted IgG heavy-chain glycan. S2 indicates the fully sialylated glycoform G0, and brackets indicate the extent of the G0 glycoform. LCA indicates the binding site for the LCA used in lectin experiments and EndoS the cleavage site for the enzyme. (B) Structural model of human IgG. IgG heavy chains are colored blue, and the light chains are colored red. Brackets indicate the antigen-binding Fab′ portion and the Fc effector portion of IgG. Arrow indicates the two conserved glycans (yellow) attached to Asn-297 of the heavy chains. The model was generated by using VMD 1.8.5 from a model deposited in the Protein Data Bank by M. Clark (Cambridge University, Cambridge, U.K.).