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. 2008 Mar 12;105(11):4277–4282. doi: 10.1073/pnas.0708647105

Fig. 1.

Fig. 1.

PPARδ activation attenuates AngII-accelerated atherosclerosis. Male LDLR−/− mice were treated with HF/PBS, HF/AngII, or HF/AngII/GW0742 (1 mpk or 10 mpk) for 4 weeks. (A) Aortic PPARδ mRNA expression after 2 and 4 weeks of HF/AngII treatment. Data are mean ± SD (n = 12 per group). *, P < 0.01 vs. HF. (B) Localization of aorta PPARδ protein expression by immunohistochemistry. PPARδ protein expression localized predominantly to macrophage-rich areas (CD68-positive intimal layer) and intimal vascular smooth muscle cells in lesions. (Magnification: ×40.) (C) Representative Sudan IV-stained aortas. (D) Quantification of en face atherosclerotic lesion coverage. Data are mean ± SD (n = 8 per group). *, P < 0.01 vs. HF/AngII by ANOVA.