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PPARδ activation inhibits AngII-induced phosphorylation of MAP kinases. Mouse peritoneal macrophages stimulated with AngII in the presence or absence of GW0742 were analyzed by Western blot for MAP kinase activation. Activation of p38 (A) and ERK1/2 (B) was measured by the levels of phosphorylated p38 (pp38) and ERK1/2 (pERK1/2) normalized to total p38 and ERK1/2. n = 3 per group. *, P < 0.05 vs. AngII by ANOVA.
