Table 1.
Characteristics of AngII-infused HF-fed LDLR−/− mice treated with or without PPARδ ligand
| Characteristics | HF/AngII | HF/AngII/1 mpk GW | HF/AngII/10mpk GW |
|---|---|---|---|
| Initial BW (g) | 25.5 ± 2.2 | 26.5 ± 1.3 | 26.6 ± 1.3 |
| Final BW (g) | 21.6 ± 1.4 | 20.5 ± 1.5 | 20.1 ± 1.2 |
| Intial BP (mm Hg) | 108.0 ± 6.5 | 100.2 ± 5.9 | 103.3 ± 6.5 |
| Final BP (mm Hg) | 155.6 ± 11.6 | 168.5 ± 16.8 | 171.4 ± 14.3 |
| Triglycerides (mg/dL) | 160.0 ± 18.2 | 115.0 ± 8.5* | 65.0 ± 14.0* |
| Cholesterol (mg/dL) | 1273 ± 78.7 | 1035. ± 35.8* | 1140 ± 1.3* |
| HDL (mg/dL) | 78.0 ± 2.0 | 115.0 ± 4.3* | 48.0 ± 4.0* |
| Fatty acids (mg/dL) | 58.0 ± 2.0 | 43.0 ± 1.6* | 36.0 ± 1.9* |
| Glucose (mg/dL) | 241.0 ± 16.9 | 207.0 ± 10.7 | 153.0 ± 9.6* |
| Insulin (mg/dL) | 762 ± 94 | 718 ± 109 | 575 ± 82* |
| Resistin (pg/mL) | 1483 ± 94 | 1298 ± 160 | 1112 ± 147 |
| Leptin (pg/mL) | 1041 ±72 | 397 ± 85* | 330 ± 82* |
| MCP-1 (pg/mL) | 89.0 ± 20.0 | 12.2 ± 2.0* | 12.1 ± 12.0* |
| PAI-1 (pg/mL) | 4742 ± 316 | 2337 ± 322* | 3630 ± 410 |
BW, body weight; BP, blood pressure. Means ± SD. *, P < 0.05 vs. HF/AngII.