Fig. 3.

Average network connectivity for disease genes with different phenotypes. Data are shown separately for the GW (Left) and Y2H (Right) networks. Light-gray columns show the average connectivity for disease genes displaying decrease/no-decrease in life expectancy. Dark-gray columns show the average connectivity of disease genes with recessive/dominant phenotypes. The error bars represent one standard error. Because the connectivity distributions for each category are not parametric, we used the Mann–Whitney test to determine significance of the difference between categories.