Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2003 Jul 1;89(1):185–191. doi: 10.1038/sj.bjc.6601048

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2003 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Enhancement of drug-induced apoptosis by the PI-3K-specific inhibitor LY294002 and the MEK-specific inhibitor PD98059 on MCF7RasG12V cells. MCF7RasG12V cells were cultured for a 16-h pre-drug period with or without 20 μm LY294002 or 40 μm PD98059, 8-h pulse exposure of the cells to 2.5 μm doxorubicin (A), 5 μm paclitaxel (B), or 40 mm 5-fluorouracil (C), and a 16-h postdrug period in 10% CS-FBS. Cells were then harvested for apoptosis ELISA. The statistical differences between LY294002 and PD98059 in enhancing the cytotoxicity of drugs (doxorubicin, paclitaxel, or 5-fluorouracil) were calculated by Student's t-test.