Table 6. Meta-analysis of the studies performed in squamous cell cancer, with their characteristics.
|
Group of squamous cell cancer (n=5) | |||||||
|---|---|---|---|---|---|---|---|
| Study | Method | Threshold | QS (%) | N Pts | Bcl-2+ (%) | HR | 95% CI |
| Chen et al (1999) | IHC-clone 124 | NM | 33 | 40 | 42 | 0.18 | 0.03–0.88 |
| Ghosh et al (1999) | IHC-clone 124 | >50 | 41 | 134 | 31 | 0.6 | 0.40–0.89 |
| Higashiyama et al (1997) | IHC-clone 124 | >10 | 52 | 67 | 31 | 0.32 | 0.08–1.25 |
| O'Neill et al (1996) | IHC-clone 124 | >1 | 55 | 54 | 35 | 1.34 | 0.52–3.44 |
| Pezzella et al (1993) | IHC-clone 100 | NM | 65 | 75 | 27 | 0.42 | 0.20–0.91 |
| Overall (fixed-effects model) | 370 | 32 | 0.57 | 0.41–0.78 | |||
| Overall (random-effects model) | 0.54 | 0.33–0.89 | |||||
| χ2 statistic for heterogeneity=6.67, 4 df; P=0.15 | |||||||
The meaning of the symbols is described in Table 3.