Table 5. Other toxicities. Common toxicity criteria grades 3 and 4.

	Dose level 1	Dose level 2	Dose level 3	Dose level 4
	3 patients	3 patients	16 patients	6 patients
Pain/headaches	0	0	1	1
Stomatitis	0	0	0	0
Infection	0	0	1a	0
Skin rash	0	0	2	0
Raised (ALT) transaminases	0	1	1b	1a
Raised bilirubin	0	0	1b	0

^aTemozolomide alone.

^bHepatitis A infection, one patient.