Table 1. Influence of diet on plasma glucose, β-OHB, and IGF-1 levels in mice bearing the CT-2A intracerebral brain tumour.
| Dietb | Groupsc | Glucose (mmol l−1) | β-OHB (mmol l−1) | IGF-1 (ng ml−1) |
|---|---|---|---|---|
| SD | UR | 9.1±0.9 | 0.6±0.1 | 208±25 |
| (7)d | (7) | (6) | ||
| R | 5.2±1.1* | 1.4±0.2* | 117±36* | |
| (6) | (6) | (6) | ||
| KD | UR | 11.4±1.4 | 1.0±0.3 | 294±30 |
| (14) | (14) | (5) | ||
| R | 5.7±1.5* | 1.3±0.6 | 193±57* | |
| (6) | (6) | (6) |
a
Values are expressed as means ±95% confidence intervals as described in Materials and Methods.
b
Animals were fed either a standard chow diet (SD) or a ketogenic diet (KD).
c
UR(unrestricted feeding) and R (restricted to 60% of the SD-UR group as described in Materials and Methods).
d
Numbers in parentheses indicate the number of independent tumour-bearing mice examined in each group. The asterisks indicate that the values of the R groups differed from those of their respective UR groups at P < 0.01 (analysed by ANOVA, one-way).